| MLS 2021 | ||||
| 1ª Semana | ||||
| 16-abr-2021 | Houston | Dynamo | 2 | Rodriguez, Urruti |
| Earthquakes | 1 | Marie | ||
| 16-abr-2021 | Seattle | Sounders | 4 | Joao Paulo, Ruidiaz (2), Montero |
| Minnesota United | 0 | |||
| 17-abr-2021 | Fort Lauderdale | Impact | 4 | Toye, Quioto, Wanyama, Mihailovic |
| Toronto | 2 | Delgado (P), Laryea | ||
| 17-abr-2021 | Orlando | Orlando City | 0 | |
| Atlanta United | 0 | |||
| 17-abr-2021 | Los Angeles | Los Angeles | 2 | Baird, Cifuentes |
| Austin | 0 | |||
| 17-abr-2021 | Washington | DC United | 2 | Hines-Ike, Canouse |
| New York City | 1 | Castellanos | ||
| 17-abr-2021 | Harrison | Red Bulls | 1 | Clark |
| Sporting | 2 | Kinda (P), Salloi | ||
| 17-abr-2021 | Frisco | Dallas | 0 | |
| Rapids | 0 | |||
| 17-abr-2021 | Chicago | Fire | 2 | Beric, Stojanovic |
| Revolution | 2 | Buksa, Bou | ||
| 17-abr-2021 | Nashville | Nashville | 2 | Cadiz, Leal |
| Cincinnati | 2 | Acosta, Brenner (P) | ||
| 18-abr-2021 | Fort Lauderdale | Inter | 2 | Robinson, Higuain (P) |
| Galaxy | 3 | Hernandez (2), Kljestan | ||
| 18-abr-2021 | Columbus | Crew | 0 | |
| Union | 0 | |||
| 18-abr-2021 | Sandy | Whitecaps | 1 | Cavallini |
| Timbers | 0 | |||
| 2ª Semana | ||||
| 23-abr-2021 | Kansas City | Sporting | 1 | Busio |
| Orlando City | 1 | Nani | ||
| 24-abr-2021 | Bronx | New York City | 5 | Medina (2), Hagglund (A), Thorarinsson, Castellanos |
| Cincinnati | 0 | |||
| 24-abr-2021 | Nashville | Nashville | 2 | Cadiz, Mukhtar |
| Impact | 2 | Toye, Brault-Guillard | ||
| 24-abr-2021 | Orlando | Toronto | 2 | Singh, Osorio |
| Whitecaps | 2 | Dajome (P), Rose | ||
| 24-abr-2021 | San Jose | Earthquakes | 3 | Alanis (P), Espinoza, Cowell |
| Dallas | 1 | Pepi | ||
| 24-abr-2021 | Los Angeles | Los Angeles | 1 | Atuesta |
| Sounders | 1 | Smith | ||
| 24-abr-2021 | Atlanta | Atlanta United | 3 | Barco, Kappelhof (A), Hyndman |
| Fire | 1 | Stojanovic | ||
| 24-abr-2021 | Saint Paul | Minnesota Unitred | 1 | Lod |
| Real Salt Lake | 2 | Julio (2) | ||
| 24-abr-2021 | Foxborough | Revolution | 1 | Hines-Ike (A) |
| DC United | 0 | |||
| 24-abr-2021 | Chester | Union | 1 | Jamiro Monteiro |
| Inter | 2 | G. Higuain, F. Higuain | ||
| 24-abr-2021 | Commerce City | Rapids | 1 | Shinyashiki |
| Austin | 3 | Fagundez, Dominguez (2) | ||
| 24-abr-2021 | Portland | Timbers | 2 | Asprilla, Paredes |
| Dynamo | 1 | Paredes (A) | ||
| 25-abr-2021 | Carson | Galaxy | 3 | Hernandez (3) |
| Red Bulls | 2 | Gutman, Casseres | ||
| 3ª Semana | ||||
| 1-may-2021 | Harrison | Red Bulls | 2 | Casseres, Clark |
| Fire | 0 | |||
| 1-may-2021 | Sandy | Real Salt Lake | 3 | Kreilach, Mendez (2) |
| Sporting | 1 | Pulido | ||
| 1-may-2021 | Fort Lauderdale | Impact | 0 | |
| Crew | 0 | |||
| 1-may-2021 | Houston | Dynamo | 1 | Pasher |
| Los Angeles | 1 | Baird | ||
| 1-may-2021 | Foxborough | Revolution | 2 | Bye, Gil (P) |
| Atlanta United | 1 | Moreno (P) | ||
| 1-may-2021 | Orlando | Orlando | 3 | Akindele, Nani, Junior Urso |
| Cincinnati | 0 | |||
| 1-may-2021 | Chester | Union | 0 | |
| New York City | 2 | Medina, Castellanos | ||
| 1-may-2021 | Frisco | Dallas | 4 | Ricaurte, Obrian, Bressan, Sealy |
| Timbers | 1 | Williamson | ||
| 1-may-2021 | Saint Paul | Minnesota United | 0 | |
| Austin | 1 | Fagundez | ||
| 2-may-2021 | San Jose | Earthquakes | 4 | Lopez, Cowell, Yueill (2) |
| DC United | 1 | Alfaro | ||
| 2-may-2021 | Nashville | Nashville | 0 | |
| Inter | 0 | |||
| 2-may-2021 | Seattle | Sounders | 3 | Ruidiaz (2), Smith |
| Galaxy | 0 | |||
| 2-may-2021 | Sandy | Whitecaps | 0 | |
| Rapids | 1 | Rubio | ||
| 4ª Semana | ||||
| 7-may-2021 | Sandy | Real Salt Lake | 1 | Mendez |
| Earthquakes | 2 | Wondolowski (2) | ||
| 8-may-2021 | Chicago | Fire | 0 | |
| Union | 2 | Burke, Glesnes | ||
| 8-may-2021 | Harrison | Red Bulls | 2 | Amaya, Clark |
| Toronto | 0 | |||
| 8-may-2021 | Nashville | Nashville | 2 | Sapong, Muyl |
| Revolution | 0 | |||
| 8-may-2021 | Columbus | Crew | 3 | Zelarayan, Brillant (A), Alfaro (A) |
| DC United | 1 | Kamara | ||
| 8-may-2021 | Sandy | Whitecaps | 2 | Dajome (2, 1P) |
| Impact | 0 | |||
| 8-may-2021 | Frisco | Dallas | 1 | Obrian |
| Dynamo | 1 | Picault (P) | ||
| 8-may-2021 | Orlando | Orlando City | 1 | Nani |
| New York City | 1 | Castellanos (P) | ||
| 8-may-2021 | Carson | Galaxy | 2 | Hernandez, Dos Santos |
| Los Angeles | 1 | Rossi | ||
| 8-may-2021 | Commerce City | Rapids | 3 | Acosta, Bassett, Wilson |
| Minnesota United | 2 | Reynoso, Dotson | ||
| 9-may-2021 | Fort Lauderdale | Inter | 1 | Morgan |
| Atlanta United | 1 | Martinez | ||
| 9-may-2021 | Portland | Timbers | 1 | Tuiloma |
| Sounders | 2 | Ruidiaz (P), Montero | ||
| 9-may-2021 | Kansas City | Sporting | 2 | Ilie, Kinda |
| Austin | 1 | Gallagher | ||
| 5ª Semana | ||||
| 12-may-2021 | Orlando | Toronto | 2 | Bradley, Altidore |
| Columbus | 0 | |||
| 12-may-2021 | Chester | Union | 1 | Przybylko |
| Revolution | 1 | Bunbury | ||
| 12-may-2021 | Fort Lauderdale | Inter | 0 | |
| Impact | 2 | Johnsen (2) | ||
| 12-may-2021 | Houston | Dynamo | 1 | Urruti |
| Sporting | 0 | |||
| 12-may-2021 | Saint Paul | Minnesota Union | 1 | Abila |
| Whitecaps | 0 | |||
| 12-may-2021 | San Jose | Earthquakes | 0 | |
| Sounders | 1 | Roldan | ||
| 13-may-2021 | Washington | DC United | 1 | Flores |
| Fire | 0 | |||
| 15-may-2021 | Bronx | New York City | 1 | Medina |
| Toronto | 1 | Shaffelburg | ||
| 15-may-2021 | Carson | Galaxy | 2 | Lletget, Hernandez |
| Austin | 0 | |||
| 15-may-2021 | Atlanta | Atlanta United | 1 | Moreno |
| Montreal | 0 | |||
| 15-may-2021 | Chester | Union | 1 | Burke |
| Red Bulls | 0 | |||
| 15-may-2021 | Saint Paul | Minnesota United | 1 | Lod |
| Dallas | 0 | |||
| 15-may-2021 | Commerce City | Rapids | 3 | Vines, Rubio, Bassett |
| Dynamo | 1 | Ramirez | ||
| 15-may-2021 | Sandy | Real Salt Lake | 0 | |
| Nashville | 0 | |||
| 15-may-2021 | San Jose | Earthquakes | 0 | |
| Timbers | 2 | Chara, Loria | ||
| 16-may-2021 | Kansas City | Sporting | 3 | Salloi, Pulido (2, 1P) |
| Whitecaps | 0 | |||
| 16-may-2021 | Cincinnati | Cincinnati | 2 | Barreal, Hagglund |
| Inter | 3 | Shea, Higuain (2) | ||
| 16-may-2021 | Foxborough | Revolution | 1 | Buksa |
| Columbus | 0 | |||
| 16-may-2021 | Washington | DC United | 0 | |
| Orlando City | 1 | Pereyra | ||
| 16-may-2021 | Seattle | Sounders | 2 | Arreaga, Smith |
| Los Angeles | 0 | |||
| 6ª Semana | ||||
| 22-may-2021 | Fort Lauderdale | Impact | 1 | Mihailovic |
| Cincinnati | 2 | Locadia, Vallecilla | ||
| 22-may-2021 | Portland | Timbers | 3 | Mora (2), Valeri (P) |
| Galaxy | 0 | |||
| 22-may-2021 | Chicago | Fire | 1 | Stojanovic |
| Inter | 0 | |||
| 22-may-2021 | Orlando | Orlando City | 1 | Akindele |
| Toronto | 0 | |||
| 22-may-2021 | Harrison | New York City | 1 | Tajouri |
| Crew | 2 | Zelarayan (2) | ||
| 22-may-2021 | Frisco | Dallas | 2 | Jara (P), Hollingshead |
| Real Salt Lake | 2 | Mendez, Kreilach | ||
| 22-may-2021 | Foxborough | Revolution | 3 | Bou, Buchanan, Buksa |
| Red Bulls | 1 | Reyes | ||
| 22-may-2021 | Houston | Dynamo | 2 | Rodriguez, Urruti |
| Whitecaps | 1 | Caicedo | ||
| 22-may-2021 | San Jose | Earthquakes | 1 | Lopez |
| Sporting | 3 | Lindsey, Pulido, Salloi | ||
| 22-may-2021 | Los Angeles | Los Angeles | 2 | Rossi (2) |
| Rapids | 1 | Barrios | ||
| 23-may-2021 | Seattle | Sounders | 1 | Ruidiaz |
| Atlanta United | 1 | Martinez (P) | ||
| 23-may-2021 | Washington | DC United | 0 | |
| Union | 1 | Przybylko | ||
| 23-may-2021 | Nashville | Nashville | 1 | Leal |
| Austin | 0 | |||
| 7ª Semana | ||||
| 29-may-2021 | Harrison | Red Bulls | 2 | Clark, Casseres |
| Orlando City | 1 | Van der Water | ||
| 29-may-2021 | Chicago | Fire | 0 | |
| Montreal | 1 | Toye | ||
| 29-may-2021 | Cincinnati | Cincinnati | 0 | |
| Revolution | 1 | Buksa | ||
| 29-may-2021 | Columbus | Crew | 2 | Diaz, Zardes |
| Toronto | 1 | Akinola | ||
| 29-may-2021 | Atlanta | Atlanta United | 2 | Moreno, Lopez |
| Nashville | 2 | Mukhtar (2) | ||
| 29-may-2021 | Los Angeles | Los Angeles | 1 | Baird |
| New York City | 2 | Medina, Tajouri | ||
| 29-may-2021 | Carson | Galaxy | 1 | Beason (A) |
| Earthquakes | 0 | |||
| 29-may-2021 | Fort Lauderdale | Inter | 0 | |
| DC United | 3 | Kamara (2), Arriola | ||
| 29-may-2021 | Kansas City | Sporting | 3 | Busio, Pulido (P), Kinda |
| Dynamo | 2 | Vera, Urruti | ||
| 29-may-2021 | Commerce City | Rapids | 3 | Rosenberry, Tessmann (A), Barrios |
| Dallas | 0 | |||
| 29-may-2021 | Sandy | Real Salt Lake | 1 | Kreilach |
| Minnesota United | 1 | Hansen | ||
| 30-may-2021 | Chester | Union | 3 | Przybylko, Santos, Elliott |
| Timbers | 0 | |||
| 30-may-2021 | Seattle | Sounders | 0 | |
| Austin | 0 | |||
| 8ª Semana | ||||
| 12-jun-2021 | Kansas City | Sporting | 1 | Salloi |
| Austin | 1 | Dominguez | ||
| 18-jun-2021 | Harrison | Red Bulls | 2 | Fabio, Duncan |
| Nashville | 0 | |||
| 18-jun-2021 | Sandy | Real Salt Lake | 3 | Kreilach (2), Holt |
| Whitecaps | 1 | White | ||
| 19-jun-2021 | Harrison | New York City | 2 | Thiago, Tajouri |
| Revolution | 3 | Bou, Bell, McNamara | ||
| 19-jun-2021 | Cincinnati | Cincinnati | 0 | |
| Rapids | 2 | Rubio, Lewis | ||
| 19-jun-2021 | Columbus | Crew | 2 | Zardes (2) |
| Fire | 0 | |||
| 19-jun-2021 | Orlando | Toronto | 2 | Akinola, Osorio |
| Orlando City | 3 | Akindele, Nani, Junior Urso | ||
| 19-jun-2021 | Washington | DC United | 1 | Kamara (P) |
| Inter | 0 | |||
| 19-jun-2021 | Frisco | Dallas | 1 | Pepi |
| Minnesota United | 1 | Fragapane | ||
| 19-jun-2021 | Austin | Austin | 0 | |
| Earthquakes | 0 | |||
| 19-jun-2021 | Carson | Galaxy | 1 | Kljestan (P) |
| Sounders | 2 | Gomez, Ruidiaz | ||
| 19-jun-2021 | Portland | Timbers | 1 | Asprilla, Loria |
| Sporting | 1 | Lindsey | ||
| 20-jun-2021 | Los Angeles | Los Angeles | 1 | Cifuentes |
| Dynamo | 1 | Urruti | ||
| 20-jun-2021 | Atlanta | Atlanta United | 2 | Przybylko (A), Walkes |
| Union | 2 | Burke, Glesnes | ||
| 9ª Semana | ||||
| 22-jun-2021 | Orlando | Orlando City | 5 | Nani (P), Michel (2), Dike (2) |
| Earthquakes | 0 | |||
| 23-jun-2021 | Foxborough | Revolution | 3 | Buchanan, Jones, Bou |
| Red Bulls | 2 | Klimala, Reyes | ||
| 23-jun-2021 | Harrison | New York City | 1 | Tajouri |
| Whitecaps | 0 | |||
| 23-jun-2021 | Chester | Union | 1 | Monteiro |
| Crew | 0 | |||
| 23-jun-2021 | Saint Paul | Minnesota United | 2 | Fragapane, Hunou |
| Austin | 0 | |||
| 23-jun-2021 | Chicago | Fire | 0 | |
| Cincinnati | 1 | Barreal | ||
| 23-jun-2021 | Fort Lauderdale | Montreal | 0 | |
| DC United | 0 | |||
| 23-jun-2021 | Houston | Dynamo | 2 | Picault, Pasher |
| Timbers | 2 | Asprilla, Ebobisse | ||
| 23-jun-2021 | Kansa City | Sporting | 3 | Salloi (2), Hernandez |
| Rapids | 1 | Rosenberry | ||
| 23-jun-2021 | Nashville | Nashville | 3 | Maher, Haakenson (2) |
| Toronto | 2 | Osorio, Mullins | ||
| 23-jun-2021 | Seattle | Sounders | 2 | Roldan, Ruidiaz (P) |
| Real Salt Lake | 1 | Rusnak (P) | ||
| 23-jun-2021 | Los Angeles | Los Angeles | 2 | Vela, Blessing |
| Dallas | 0 | |||
| 23-jun-2021 | Sandy | Whitecaps | 1 | Bikel |
| Galaxy | 2 | Hernandez, Alvarez | ||
| 10ª Semana | ||||
| 25-jun-2021 | Fort Lauderdale | Inter | 1 | Higuain |
| Orlando City | 2 | Mueller, Nani | ||
| 26-jun-2021 | Kansa City | Sporting | 2 | Pulido, Salloi |
| Los Angeles | 1 | Kim Moon Hwan | ||
| 26-jun-2021 | Orlando | Toronto | 0 | |
| Cincinnati | 2 | Cruz, Acosta | ||
| 26-jun-2021 | Chicago | Fire | 3 | Glesnes (A), Sekulic, Pineda |
| Union | 3 | Sullivan, Burke, Sekulic (A) | ||
| 26-jun-2021 | Sandy | Real Salt Lake | 1 | Glad |
| Dynamo | 1 | Urruti | ||
| 26-jun-2021 | Nashville | Nashville | 1 | Danladi |
| Impact | 1 | Struna | ||
| 26-jun-2021 | Seattle | Sounders | 2 | Ruidiaz, Medranda |
| Whitecaps | 2 | Dajome, Cavallini | ||
| 26-jun-2021 | San Jose | Earthquakes | 1 | Cowell |
| Galaxy | 3 | Hernandez (2), Jungwirth (A) | ||
| 27-jun-2021 | Portland | Timbers | 0 | |
| Minnesota United | 1 | Hunou | ||
| 27-jun-2021 | Atlanta | Atlanta United | 0 | |
| Red Bulls | 0 | |||
| 27-jun-2021 | Harrison | New York City | 2 | Parks, Thiago |
| DC United | 1 | Robertha | ||
| 27-jun-2021 | Austin | Austin | 0 | |
| Crew | 0 | |||
| 27-jun-2021 | Frisco | Dallas | 2 | Pepi (2) |
| Revolution | 1 | Bou | ||
| 11ª Semana | ||||
| 1-jul-2021 | Austin | Austin | 4 | Gallagher, Fagundez, Ring, Jimenez |
| Timbers | 1 | Ebobisse | ||
| 3-jul-2021 | Columbus | Crew | 2 | Zardes, Farrell (A) |
| Revolution | 2 | Buchanan, Bou | ||
| 3-jul-2021 | Washington | DC United | 7 | Paredes, Robertha, Priso-Mbongue (A), Arriola, Kamara, Asad, Yow |
| Toronto | 1 | Akinola | ||
| 3-jul-2021 | Orlando | Orlando City | 1 | Mueller |
| Red Bulls | 2 | Casseres, Fabio | ||
| 3-jul-2021 | Harrison | Impact | 1 | Choiniere |
| Inter | 0 | |||
| 3-jul-2021 | Saint Paul | Minnesota United | 2 | Kallman, Abila |
| Earthquakes | 2 | Cowell, Kikanovic | ||
| 3-jul-2021 | Chicago | Fire | 3 | Aliseda (2), Frankowski |
| Atlanta United | 0 | |||
| 3-jul-2021 | Nashville | Nashville | 1 | Sapong |
| Union | 0 | |||
| 3-jul-2021 | Houston | Dynamo | 1 | Pasher |
| Cincinnati | 1 | Barreal | ||
| 3-jul-2021 | Sandy | Real Salt Lake | 0 | |
| Los Angeles | 1 | Cifuentes | ||
| 4-jul-2021 | Frisco | Dallas | 2 | Pepi, Veselinovic (A) |
| Whitecaps | 2 | Cavallini, Rose | ||
| 4-jul-2021 | Commerce City | Rapids | 1 | Barrios |
| Sounders | 1 | Roldan | ||
| 4-jul-2021 | Carson | Galaxy | 0 | |
| Sporting | 2 | Russell, Shelton | ||
| 12ª Semana | ||||
| 7-jul-2021 | Orlando | Impact | 2 | Toye (P), Quioto |
| New York City | 1 | Parks | ||
| 7-jul-2021 | Chicago | Fire | 3 | Sekulic, Beric, Nnamdi |
| Orlando City | 1 | Perea | ||
| 7-jul-2021 | Seattle | Sounders | 2 | Rowe, Ruidiaz |
| Dynamo | 0 | |||
| 7-jul-2021 | Commerce City | Rapids | 2 | Galvan, Shinyashiki |
| Minnesota United | 0 | |||
| 7-jul-2021 | Austin | Austin | 0 | |
| Los Angeles | 2 | Cifuentes, Rossi | ||
| 7-jul-2021 | Sandy | Whitecaps | 0 | |
| Real Salt Lake | 4 | Kreilach (2), Rusnak (P), Julio | ||
| 7-jul-2021 | Carson | Galaxy | 3 | Raveloson, Cabral, Zubak |
| Dallas | 1 | Jara | ||
| 8-jul-2021 | Harrison | Red Bulls | 1 | Klimala (P) |
| Union | 1 | Sergio Santos | ||
| 8-jul-2021 | Nashville | Nashville | 2 | Anibaba, Mukhtar (P) |
| Atlanta United | 2 | Walkes, Conway | ||
| 9-jul-2021 | Cincinnati | Cincinnati | 2 | Castillo, Acosta |
| Crew | 2 | Zelarayan, Berry | ||
| 13ª Semana | ||||
| 17-jul-2021 | Atlanta | Atlanta United | 0 | |
| Revolution | 1 | Bou | ||
| 17-jul-2021 | Columbus | Crew | 2 | Nagbe, Zelarayan |
| New York City | 1 | Medina | ||
| 17-jul-2021 | Chester | Union | 2 | Sergio Santos, Przybylko |
| DC United | 1 | Asad (P) | ||
| 17-jul-2021 | Toronto | Toronto | 1 | Altidore |
| Orlando City | 1 | Nani (P) | ||
| 17-jul-2021 | Montreal | Montreal | 5 | Toye (2, 1P), Torres, Hamdi (2) |
| Cincinnati | 4 | Medunjanin, Brenner (2), Vallecilla | ||
| 17-jul-2021 | Nashville | Nashville | 5 | Mukhtar (3), Sapong, Anunga |
| Fire | 1 | Aliseda | ||
| 17-jul-2021 | Commerce City | Rapids | 1 | Bassett |
| Earthquakes | 1 | Lopez | ||
| 17-jul-2021 | Sandy | Whitecaps | 2 | Caicedo, Dajome |
| Galaxy | 1 | Raveloson | ||
| 17-jul-2021 | Los Angeles | Los Angeles | 2 | Rossi, Vela |
| Real Salt Lake | 1 | Herrera | ||
| 17-jul-2021 | Portland | Timbers | 1 | Ebobisse |
| Dallas | 0 | |||
| 18-jul-2021 | Saint Paul | Minnesota United | 1 | Lod |
| Sounders | 0 | |||
| 14ª Semana | ||||
| 20-jul-2021 | Vancouver | Whitecaps | 0 | |
| Dynamo | 0 | |||
| 21-jul-2021 | Columbus | Crew | 0 | |
| Nashville | 0 | |||
| 21-jul-2021 | Fort Lauderdale | Inter | 0 | |
| Real Salt Lake | 5 | Traustason (2), Bunbury, Buksa (2) | ||
| 21-jul-2021 | Toronto | Toronto | 1 | Priso-Mbongue |
| Red Bulls | 1 | Klimala | ||
| 21-jul-2021 | Harrison | New York City | 1 | Tajouri |
| Montreal | 0 | |||
| 21-jul-2021 | Cincinnati | Cincinnati | 1 | Acosta |
| Atlanta United | 1 | Hernandez | ||
| 21-jul-2021 | Chicago | Fire | 2 | Gimenez, Najar (A) |
| DC United | 2 | Paredes, Kamara (P) | ||
| 21-jul-2021 | Kansas City | Sporting | 1 | Salloi |
| Earthquakes | 1 | Nathan | ||
| 21-jul-2021 | Commerce City | Rapids | 2 | Abubakar, Barrios |
| Dallas | 0 | |||
| 21-jul-2021 | Sandy | Real Salt Lake | 2 | Rusnak, Chang |
| Galaxy | 2 | Vazquez, Raveloson | ||
| 21-jul-2021 | Portland | Timbers | 2 | Valeri, Mora |
| Los Angeles | 1 | Vela | ||
| 22-jul-2021 | Orlando | Orlando City | 2 | Michel, Perea |
| Union | 1 | Przybylko | ||
| 22-jul-2021 | Austin | Austin | 0 | |
| Sounders | 1 | Ruidiaz | ||
| 24-jul-2021 | Atlanta | Atlanta United | 0 | |
| Crew | 1 | Mensah | ||
| 24-jul-2021 | Saint Paul | Minnesota United | 2 | Gasper, Lod |
| Timbers | 1 | Mora | ||
| 24-jul-2021 | Chicago | Fire | 1 | Medran |
| Toronto | 2 | Soteldo, DeLeon | ||
| 24-jul-2021 | Frisco | Dallas | 4 | Pepi (3), Obrian |
| Galaxy | 0 | |||
| 24-jul-2021 | Nashville | Nashville | 3 | Sapong (2), Leal |
| Cincinnati | 0 | |||
| 24-jul-2021 | San Jose | Earthquakes | 1 | Valentin (A) |
| Dynamo | 1 | Vera | ||
| 24-jul-2021 | Sandy | Real Salt Lake | 3 | Yarbrough (A), Wood, Mendez |
| Rapids | 0 | |||
| 24-jul-2021 | Los Angeles | Los Angeles | 2 | Vela, Cifuentes |
| Whitecaps | 2 | Caicedo, Dajome | ||
| 25-jul-2021 | Bronx | New York City | 5 | Medina, Tajouri, Moralez, Amundsen, Castellanos |
| Orlando City | 0 | |||
| 25-jul-2021 | Foxborough | Revolution | 2 | Bou (2) |
| Impact | 1 | Mihailovic | ||
| 25-jul-2021 | Fort Lauderdale | Inter | 1 | Robinson |
| Union | 1 | Przybylko | ||
| 25-jul-2021 | Washington | DC United | 1 | Kamara |
| Red Bulls | 0 | |||
| 25-jul-2021 | Seattle | Sounders | 1 | Montero |
| Sporting | 3 | Russell, Salloi, Duke | ||
| 15ª Semana | ||||
| 28-jul-2021 | Los Angeles | Los Angeles | 2 | Vela, Blackmon |
| Minnesota United | 2 | Reynoso, Dotson | ||
| 30-jul-2021 | Bronx | New York City | 4 | Castellanos, Thiago, Parks, Rodriguez |
| Crew | 1 | Pedro Santos (P) | ||
| 30-jul-2021 | Orlando | Orlando City | 3 | Smith, Van der Water, Nani |
| Atlanta United | 2 | Martinez, Moreno | ||
| 30-jul-2021 | Carson | Galaxy | 4 | Raveloson, Vazquez, Kljestan (P), Grandsir |
| Timbers | 1 | Ebobisse | ||
| 31-jul-2021 | Seattle | Sounders | 0 | |
| Earthquakes | 1 | Espinoza | ||
| 31-jul-2021 | Harrison | Red Bulls | 2 | Carmona, Fabio |
| Revolution | 3 | Bou, Bye, Buksa | ||
| 31-jul-2021 | Cincinnati | Cincinnati | 0 | |
| DC United | 0 | |||
| 31-jul-2021 | Fort Lauderdale | Inter | 2 | Higuain (2, 1P) |
| Impact | 1 | Torres | ||
| 31-jul-2021 | Houston | Dynamo | 0 | |
| Real Salt Lake | 0 | |||
| 31-jul-2021 | Kansas City | Sporting | 1 | Russell |
| Dallas | 2 | Pomykal, Ferreira | ||
| 31-jul-2021 | Austin | Austin | 0 | |
| Rapids | 1 | Shinyashiki | ||
| 31-jul-2021 | Sandy | Whitecaps | 2 | Dajome (2, 1P) |
| Minnesota United | 2 | Finlay, Lod | ||
| 1-ago-2021 | Chester | Union | 1 | Wagner |
| Fire | 1 | Frankowski | ||
| 1-ago-2021 | Toronto | Toronto | 1 | Gonzalez |
| Nashville | 1 | Castellanos | ||
| 16ª Semana | ||||
| 4-ago-2021 | Foxborough | Revolution | 0 | |
| Nashville | 0 | |||
| 4-ago-2021 | Columbus | Crew | 2 | Molino, Zelarayan |
| DC United | 4 | Kamara (2, 1P), Reyna (2) | ||
| 4-ago-2021 | Chester | Union | 3 | Glesnes, Gazdag (P), Santos |
| Toronto | 0 | |||
| 4-ago-2021 | Montreal | Impact | 2 | Toye, Camacho |
| Atlanta United | 2 | Martinez, Moreno (P) | ||
| 4-ago-2021 | Orlando | Orlando City | 1 | Antonio Carlos |
| Inter | 1 | Gibbs | ||
| 4-ago-2021 | Chicago | Fire | 0 | |
| New York City | 0 | |||
| 4-ago-2021 | Harrison | Red Bulls | 0 | |
| Cincinnati | 0 | |||
| 4-ago-2021 | Austin | Austin | 3 | Pochettino (2), Dominguez |
| Dynamo | 2 | Pasher, Picault | ||
| 4-ago-2021 | Seattle | Sounders | 1 | Montero |
| Dallas | 1 | Jara | ||
| 4-ago-2021 | Los Angeles | Los Angeles | 1 | Musovski |
| Sporting | 4 | Pulido, Martins, Salloi, Kinda | ||
| 4-ago-2021 | Portland | Timbers | 1 | Mora |
| Earthquakes | 1 | Lopez | ||
| 4-ago-2021 | Carson | Galaxy | 1 | Alvarez |
| Real Salt Lake | 0 | |||
| 7-ago-2021 | Cincinnati | Cincinnati | 1 | Brenner |
| Orlando City | 1 | Nani | ||
| 7-ago-2021 | Columbus | Crew | 2 | Mensah, Pedro Santos (P) |
| Atlanta United | 3 | Barco (2, 1P), Moreno (P) | ||
| 7-ago-2021 | Saint Paul | Minnesota United | 2 | Lod, Kallman |
| Dynamo | 0 | |||
| 7-ago-2021 | Toronto | Toronto | 2 | Laryea, Pozuelo |
| New York City | 2 | Rodriguez, Tajouri | ||
| 7-ago-2021 | Frisco | Dallas | 2 | Hollingshead, Ferreira |
| Austin | 0 | |||
| 7-ago-2021 | Commerce City | Rapids | 0 | |
| Sporting | 0 | |||
| 7-ago-2021 | Portland | Timbers | 3 | Asprilla (P), Chara, Mora |
| Real Salt Lake | 2 | Rusnak, Kreilach | ||
| 8-ago-2021 | Chicago | Fire | 2 | Stojanovic (2) |
| Red Bulls | 1 | Barlow | ||
| 8-ago-2021 | Fort Lauderdale | Inter | 2 | Higuain, Vassilev |
| Nashville | 1 | Sapong | ||
| 8-ago-2021 | Foxborough | Revolution | 2 | Polster, Bou |
| Union | 1 | Aaronson | ||
| 8-ago-2021 | San Jose | Earthquakes | 2 | Nathan, Lopez |
| Los Angeles | 1 | Yueill (A) | ||
| 8-ago-2021 | Carson | Galaxy | 1 | Cabral |
| Whitecaps | 1 | Veselinovic | ||
| 8-ago-2021 | Washington | DC United | 2 | Najar, Kamara |
| Impact | 1 | Brault-Guillard | ||
| 17ª Semana | ||||
| 13-ago-2021 | San Jose | Earthquakes | 0 | |
| Whitecaps | 0 | |||
| 14-ago-2021 | Saint Paul | Minnesota United | 0 | |
| Galaxy | 1 | Cabral | ||
| 14-ago-2021 | Harrison | New York City | 2 | Castellanos (2, 1P) |
| Inter | 0 | |||
| 14-ago-2021 | Toronto | Toronto | 1 | Osorio |
| Revolution | 2 | Buchanan, Bou (P) | ||
| 14-ago-2021 | Montreal | Impact | 2 | Sunusi, Wanyama (P) |
| Red Bulls | 1 | Klimala (P) | ||
| 14-ago-2021 | Frisco | Dallas | 0 | |
| Sporting | 2 | Puliso, Salloi | ||
| 14-ago-2021 | Houston | Dynamo | 1 | Picault (P) |
| Rapids | 3 | Abubakar, Barrios, Galvan | ||
| 14-ago-2021 | Sandy | Real Salt Lake | 1 | Wood |
| Austin | 0 | |||
| 15-ago-2021 | Atlanta | Atlanta United | 1 | Martinez |
| Los Angeles | 0 | |||
| 15-ago-2021 | Chicago | Fire | 1 | Stojanovic |
| Crew | 0 | |||
| 15-ago-2021 | Nashville | Nashville | 5 | Sapong (2), Mukhtar, Muyl (2, 1P) |
| DC United | 2 | Brillant, Kamara | ||
| 15-ago-2021 | Portland | Timbers | 2 | Blanco, Fochive |
| Sounders | 6 | Montero (2), Ruidiaz (2), Medranda, Benezet | ||
| 18ª Semana | ||||
| 17-ago-2021 | Carson | Galaxy | 1 | Raveloson |
| Rapids | 2 | Lewis (P), Shinyashiki | ||
| 17-ago-2021 | San Jose | Earthquakes | 1 | Dibassy (A) |
| Minnesota United | 1 | Trapp | ||
| 18-ago-2021 | Foxborough | Revolution | 3 | McNamara, Buchanan, Jones |
| DC United | 2 | Arriola, Abila | ||
| 18-ago-2021 | Atlanta | Atlanta United | 1 | Barco |
| Toronto | 0 | |||
| 18-ago-2021 | Fort Lauderdale | Inter | 3 | Vassilev, Robinson, Pizarro |
| Fire | 2 | Calvo, Stojanovic | ||
| 18-ago-2021 | Chester | Union | 1 | Bedoya |
| New York City | 0 | |||
| 18-ago-2021 | Cincinnati | Cincinnati | 0 | |
| Impact | 0 | |||
| 18-ago-2021 | Harrison | Red Bulls | 1 | Tolkin |
| Crew | 0 | |||
| 18-ago-2021 | Frisco | Dallas | 0 | |
| Sounders | 1 | Ruidiaz | ||
| 18-ago-2021 | Nashville | Nashville | 1 | Sapong |
| Orlando City | 1 | Antonio Carlos | ||
| 18-ago-2021 | Kansas City | Sporting | 1 | Salloi |
| Timbers | 1 | Mora | ||
| 18-ago-2021 | Austin | Austin | 1 | Ring |
| Whitecaps | 2 | Nerwinski, White | ||
| 18-ago-2021 | Sandy | Real Salt Lake | 2 | Meram, Julio |
| Dynamo | 1 | Picault | ||
| 19ª Semana | ||||
| 20-ago-2021 | Carson | Galaxy | 1 | Vazquez |
| Earthquakes | 2 | Ebobisse, Hamalainen (A) | ||
| 21-ago-2021 | Saint Paul | Minnesota United | 0 | |
| Sporting | 0 | |||
| 21-ago-2021 | Columbus | Crew | 1 | Wright-Phillips |
| Sounders | 2 | Arreaga, Bruin | ||
| 21-ago-2021 | Washington | DC United | 1 | Reyna |
| Atlanta United | 2 | Martinez, Moreno | ||
| 21-ago-2021 | Foxborough | Revolution | 4 | Buchanan, Boateng, Buksa (2) |
| Cincinnati | 1 | Brenner | ||
| 21-ago-2021 | Fort Lauderdale | Inter | 3 | Pizarro (2), Robinson |
| Toronto | 1 | Gibbs (A) | ||
| 21-ago-2021 | Chester | Union | 1 | Sullivan |
| Montreal | 1 | Mihailovic | ||
| 21-ago-2021 | Houston | Dynamo | 2 | Picault (P), Vera |
| Dallas | 2 | Burgess, Pepi | ||
| 21-ago-2021 | Orlando | Orlando City | 1 | Michel |
| Fire | 0 | |||
| 21-ago-2021 | Austin | Austin | 3 | Dominguez (P), Fagundez, Driussi |
| Timbers | 1 | Asprilla | ||
| 21-ago-2021 | Commerce City | Rapids | 2 | Rubio, Kaye |
| Real Salt Lake | 1 | Rusnak | ||
| 21-ago-2021 | Vancouver | Whitecaps | 2 | White, Gauld |
| Los Angeles | 1 | Rossi (P) | ||
| 20ª Semana | ||||
| 27-ago-2021 | Columbus | Crew | 3 | Zelarayan, Berry (2) |
| Cincinnati | 2 | Matarrita, Atanga | ||
| 27-ago-2021 | Montreal | Impact | 3 | Piette, Torres, Quioto |
| Toronto | 1 | Achara | ||
| 27-ago-2021 | Orlando | Orlando City | 0 | |
| Inter | 0 | |||
| 28-ago-2021 | Atlanta | Atlanta United | 0 | |
| Nashville | 2 | Rios, Leal | ||
| 28-ago-2021 | Harrison | Red Bulls | 0 | |
| Fire | 1 | Beric | ||
| 28-ago-2021 | Los Angeles | Los Angeles | 3 | Arango (P), Rodriguez (2) |
| Galaxy | 3 | Joveljic (2), Cabral | ||
| 28-ago-2021 | Bronx | New York City | 2 | Castellanos (2) |
| Foxborough | 0 | |||
| 28-ago-2021 | Washington | DC United | 3 | Kamara (P), Reyna, Abila |
| Union | 1 | Birnbaum (A) | ||
| 28-ago-2021 | Houston | Dynamo | 1 | Carrasquilla |
| Minnesota United | 2 | Hunou (2) | ||
| 28-ago-2021 | Kansas City | Sporting | 1 | Russell |
| Rapids | 1 | Lewis | ||
| 29-ago-2021 | Austin | Austin | 3 | Cascante, Fagundez, Ring |
| Dallas | 5 | Ferreira (2), Pepi (2), Obrian | ||
| 29-ago-2021 | Vancouver | Whitecaps | 4 | Silva (A), White, Gauld, Jungwirth |
| Real Salt Lake | 1 | Julio | ||
| 29-ago-2021 | Seattle | Sounders | 0 | |
| Timbers | 2 | Blanco, Mora | ||
| 21ª Semana | ||||
| 3-sep-2021 | Nashville | Nashville | 3 | Mukhtar (2), Latinovich (A) |
| New York City | 1 | Castellanos | ||
| 3-sep-2021 | Chester | Union | 0 | |
| Revolution | 1 | Polster | ||
| 3-sep-2021 | Houston | Dynamo | 0 | |
| Timbers | 2 | Chara, Mora (P) | ||
| 3-sep-2021 | Los Angeles | Los Angeles | 4 | Fall (2), Arango, Atuesta (P) |
| Sporting | 0 | |||
| 4-sep-2021 | Vancouver | Whitecaps | 2 | Godoy, Caicedo |
| Austin | 1 | Driussi | ||
| 4-sep-2021 | Orlando | Orlando City | 3 | Dike, Van der Water, Urso |
| Crew | 2 | Antonio Carlos (A), Berry | ||
| 4-sep-2021 | Cincinnati | Cincinnati | 0 | |
| Inter | 1 | Shea | ||
| 4-sep-2021 | Sandy | Real Salt Lake | 3 | Glad, Menendez, Rusnak |
| Dallas | 2 | Jara, Ferreira | ||
| 4-sep-2021 | San Jose | Earthquakes | 0 | |
| Rapids | 1 | Badji | ||
| 22ª Semana | ||||
| 10-sep-2021 | Atlanta | Atlanta United | 3 | Campbell, Dike (A), Barco |
| Orlando City | 0 | |||
| 10-sep-2021 | Vancouver | Whitecaps | 0 | |
| Timbers | 1 | Veselinovic (A) | ||
| 11-sep-2021 | Commerce City | Rapids | 1 | Barrios |
| Galaxy | 1 | Grandsir | ||
| 11-sep-2021 | Seattle | Sounders | 1 | Joao Paulo |
| Minnesota United | 0 | |||
| 11-sep-2021 | Foxborough | Revolution | 2 | Boateng, Buchanan |
| New York City | 1 | Rodriguez | ||
| 11-sep-2021 | Harrison | Red Bulls | 1 | Yearwood |
| DC United | 1 | Kamara (P) | ||
| 11-sep-2021 | Fort Lauderdale | Inter | 1 | Higuain |
| Crew | 0 | |||
| 11-sep-2021 | Cincinnati | Cincinnati | 2 | Brenner, Medunjanin |
| Toronto | 0 | |||
| 11-sep-2021 | Montreal | Impact | 0 | |
| Nashville | 1 | Zimmerman | ||
| 11-sep-2021 | Frisco | Dallas | 1 | Pepi |
| Earthquakes | 1 | Alanis (P) | ||
| 11-sep-2021 | Houston | Dynamo | 3 | Dorsey, Picault (2) |
| Austin | 0 | |||
| 11-sep-2021 | Kansas City | Sporting | 2 | Mauri, Russell |
| Fire | 0 | |||
| 12-sep-2021 | Los Angeles | Los Angeles | 3 | Arango (2), Datjovic (A) |
| Real Salt Lake | 2 | Kreilach, Julio | ||
| 23ª Semana | ||||
| 14-sep-2021 | Harrison | New York City | 3 | Moralez, Medina, Talles Magno |
| Dallas | 3 | Obrian (2), Ferreira | ||
| 14-sep-2021 | Toronto | Toronto | 0 | |
| Inter | 1 | Makoun (P) | ||
| 14-sep-2021 | Columbus | Crew | 2 | Nagbe, Berry |
| Red Bulls | 1 | Klimala | ||
| 15-sep-2021 | Atlanta | Atlanta United | 4 | Luiz Araujo, Martinez (2), Barco |
| Cincinnati | 0 | |||
| 15-sep-2021 | Washington | DC United | 3 | Kamara (3, 2P) |
| Fire | 0 | |||
| 15-sep-2021 | Orlando | Orlando City | 2 | Jansson, Ruan |
| Montreal | 4 | Choiniere, Quioto, Lappalainen, Sanusi | ||
| 15-sep-2021 | Kansas City | Sporting | 4 | Shelton, Salloi, Russell (P), Duke |
| Minnesota United | 0 | |||
| 15-sep-2021 | Austin | Austin | 1 | Fagundez |
| Los Angeles | 2 | Arango (P), Musovski | ||
| 15-sep-2021 | Portland | Timbers | 2 | Mora, Blanco |
| Rapids | 2 | Lewis, Barrios | ||
| 15-sep-2021 | Carson | Galaxy | 1 | Hernandez |
| Dynamo | 1 | Picault | ||
| 15-sep-2021 | San Jose | Earthquakes | 3 | Lopez (3) |
| Real Salt Lake | 4 | Mendez (2), Rusnak, Meram | ||
| 17-sep-2021 | Fort Lauderdale | Inter | 0 | |
| Red Bulls | 4 | Klimala, Fernandez, Fabio (2) | ||
| 18-sep-2021 | Atlanta | Atlanta United | 3 | Barco, Martinez, Bello |
| DC United | 2 | Martins, Flores | ||
| 18-sep-2021 | Foxborough | Revolution | 1 | Buksa |
| Crew | 1 | Zardes | ||
| 18-sep-2021 | Cincinnati | Cincinnati | 1 | Brenner |
| New York City | 2 | Parks, Castellanos (P) | ||
| 18-sep-2021 | Toronto | Toronto | 2 | Shaffelburg, Gonzalez |
| Nashville | 1 | Sapong | ||
| 18-sep-2021 | Saint Paul | Minnesota United | 3 | Reynoso (2), Finlay |
| Galaxy | 0 | |||
| 18-sep-2021 | Austin | Austin | 3 | Driussi, Gallagher, Ring |
| Earthquakes | 4 | M. Lopez, Espinoza, J. Lopez (2, 1P) | ||
| 18-sep-2021 | Houston | Dynamo | 3 | Dorsey, Picault, Quintero (P) |
| Dallas | 2 | Obrian (2) | ||
| 18-sep-2021 | Sandy | Real Salt Lake | 1 | Kreilach |
| Sounders | 0 | |||
| 19-sep-2021 | Montreal | Impact | 2 | Quioto, Teran (A) |
| Fire | 0 | |||
| 19-sep-2021 | Chester | Union | 3 | Wagner, Przybylko (2, 1P) |
| Orlando City | 1 | Ruan | ||
| 19-sep-2021 | Portland | Timbers | 2 | Asprilla, Fochive |
| Los Angeles | 1 | Arango (P) | ||
| 19-sep-2021 | Commerce City | Rapids | 1 | Wilson |
| Whitecaps | 1 | White | ||
| 24ª Semana | ||||
| 22-sep-2021 | Fort Lauderdale | Inter | 1 | Higuain |
| Nashville | 5 | Mukhtar (2), Zimmerman, Leal, Johnston | ||
| 22-sep-2021 | Harrison | Red Bulls | 1 | Klimala (P) |
| New York City | 1 | Castellanos | ||
| 22-sep-2021 | Chicago | Fire | 2 | Teran, Gimenez |
| Revolution | 3 | Kessler, Bunbury, Gil | ||
| 25-sep-2021 | Chester | Union | 1 | Przybylko |
| Atlanta United | 0 | |||
| 25-sep-2021 | Foxborough | Revolution | 2 | Buksa, Schlegel (A) |
| Orlando City | 1 | Dike | ||
| 25-sep-2021 | Washington | DC United | 4 | Arriola (2), Birnbaum, Robertha |
| Cincinnati | 2 | Vazquez, Acosta | ||
| 25-sep-2021 | Columbus | Crew | 2 | Zardes (2) |
| Impact | 1 | Quioto | ||
| 25-sep-2021 | Bronx | New York City | 0 | |
| Red Bulls | 1 | Fernandez | ||
| 25-sep-2021 | Saint Paul | Minnesota United | 2 | Lod, Finlay |
| Dynamo | 0 | |||
| 25-sep-2021 | Commerce City | Rapids | 0 | |
| Toronto | 0 | |||
| 25-sep-2021 | San Jose | Earthquakes | 2 | Kikanovic, Lopez |
| Los Angeles | 0 | |||
| 25-sep-2021 | Vancouver | Whitecaps | 1 | White |
| Dallas | 0 | |||
| 25-sep-2021 | Portland | Timbers | 6 | Mora, Asprilla, Y. Chara, D. Chara, Niezgoda, Paredes |
| Real Salt Lake | 1 | |||
| 26-sep-2021 | Chicago | Fire | 0 | |
| Nashville | 0 | |||
| 26-sep-2021 | Kansas City | Sporting | 1 | Russell |
| Sounders | 2 | Roldan, Bruin | ||
| 26-sep-2021 | Austin | Austin | 2 | Djitte, Gaines |
| Galaxy | 0 | |||
| 25ª Semana | ||||
| 29-sep-2021 | Atlanta | Atlanta United | 1 | Martinez (P) |
| Inter | 0 | |||
| 29-sep-2021 | Toronto | Toronto | 3 | Shaffelburg, Delgado, Achara |
| Cincinnati | 2 | Matarrita, Acosta | ||
| 29-sep-2021 | Washington | DC United | 3 | Kamara (P), Gressel, Moreno |
| Minnesota United | 1 | Dibassy | ||
| 29-sep-2021 | Harrison | Red Bulls | 1 | Fernandez |
| Union | 1 | Santos | ||
| 29-sep-2021 | Montreal | Impact | 1 | Torres |
| Revolution | 4 | Jones, Buksa, Camacho (A), Bou | ||
| 29-sep-2021 | Frisco | Dallas | 1 | Pepi |
| Sporting | 3 | Salloi (2), Russell (P) | ||
| 29-sep-2021 | Chicago | Fire | 2 | Beric, Navarro |
| New York City | 0 | |||
| 29-sep-2021 | Nashville | Nashville | 2 | Mukhtar, Leal |
| Orlando City | 2 | Dike (P), Anunga (A) | ||
| 29-sep-2021 | Commerce City | Rapids | 3 | Lewis, Mezquida, Trusty |
| Austin | 0 | |||
| 29-sep-2021 | Houston | Dynamo | 0 | |
| Whitecaps | 0 | |||
| 29-sep-2021 | Sandy | Real Salt Lake | 2 | Kreilach, Julio |
| Galaxy | 1 | Hernandez | ||
| 29-sep-2021 | Los Angeles | Los Angeles | 1 | Musovski |
| Timbers | 2 | Chara, Asprilla | ||
| 29-sep-2021 | San Jose | Earthquakes | 1 | O'Neill (A) |
| Sounders | 3 | Ruidiaz (2, 1P), Roldan | ||
| 2-oct-2021 | Austin | Austin | 2 | Dominguez (2) |
| Real Salt Lake | 1 | Kreilach | ||
| 2-oct-2021 | Montreal | Impact | 2 | Quioto (2, 1P) |
| Atlanta United | 1 | Mulraney | ||
| 2-oct-2021 | Cincinnati | Cincinnati | 0 | |
| Red Bulls | 1 | Gutman | ||
| 2-oct-2021 | Orlando | Orlando City | 2 | Jansson, Dike |
| DC United | 1 | Gressel | ||
| 2-oct-2021 | Frisco | Dallas | 0 | |
| Minnesota United | 0 | |||
| 2-oct-2021 | Vancouver | Whitecaps | 3 | White (3) |
| Earthquakes | 0 | |||
| 3-oct-2021 | Harrison | New York City | 0 | |
| Nashville | 0 | |||
| 3-oct-2021 | Chester | Union | 3 | Elliott, Bedoya, Flach |
| Crew | 0 | |||
| 3-oct-2021 | Kansa City | Sporting | 4 | Russell (2, 1P), Salloi, Kinda |
| Dynamo | 2 | Picault, Quintero | ||
| 3-oct-2021 | Toronto | Toronto | 3 | Delgado, Gonzalez, Soteldo |
| Fire | 1 | Beric | ||
| 3-oct-2021 | Portland | Timbers | 1 | Niezgoda |
| Inter | 0 | |||
| 3-oct-2021 | Carson | Galaxy | 1 | Grandsir |
| Los Angeles | 1 | Fall | ||
| 3-oct-2021 | Seattle | Sounders | 3 | Roldan, Medranda, Joao Paulo |
| Rapids | 0 | |||
| 26ª Semana | ||||
| 9-oct-2021 | Harrison | Red Bulls | 1 | Klimala |
| Inter | 0 | |||
| 9-oct-2021 | Cincinnati | Cincinnati | 1 | Medunjanin |
| Union | 2 | Przybylko, Aaronson | ||
| 9-oct-2021 | Seattle | Sounders | 4 | O'Neill, Benezet, Bruin, Chu |
| Whitecaps | 1 | White | ||
| 10-oct-2021 | Saint Paul | Minnesota United | 1 | Hunou |
| Rapids | 3 | Bassett (P), Barrios, Esteves | ||
| 27ª Semana | ||||
| 16-oct-2021 | Montreal | Impact | 2 | Miljevic, Sunusi |
| Union | 2 | Pantemis (A), Wagner | ||
| 16-oct-2021 | Los Angeles | Los Angeles | 3 | Masovski, Arango (2, 1P) |
| Earthquakes | 1 | Fierro | ||
| 16-oct-2021 | Crew | Columbus | 4 | Zardes (2), Pedro Santos, Gonzalez (A) |
| Inter | 0 | |||
| 16-oct-2021 | Foxborough | Revolution | 2 | Kaptoum, Bou |
| Fire | 2 | Medran, Aliseda | ||
| 16-oct-2021 | Cincinnati | Cincinnati | 0 | |
| Orlando City | 4 | Junior Urso | ||
| 16-oct-2021 | Washington | DC United | 0 | |
| Nashville | 0 | |||
| 16-oct-2021 | Toronto | Toronto | 0 | |
| Atlanta United | 2 | Luiz Araujo, Moreno | ||
| 16-oct-2021 | Houston | Dynamo | 2 | Urruti, Quintero |
| Sounders | 1 | Medranda | ||
| 16-oct-2021 | Austin | Austin | 0 | |
| Minnesota United | 1 | Fragapane | ||
| 16-oct-2021 | Sandy | Real Salt Lake | 3 | Kreilach, Mendez, Julio |
| Rapids | 1 | Namli | ||
| 16-oct-2021 | Carson | Galaxy | 2 | Hernandez, Kljestan (P) |
| Timbers | 1 | Blanco | ||
| 17-oct-2021 | Harrison | Red Bulls | 1 | Casseres |
| New York City | 0 | |||
| 17-oct-2021 | Vancouver | Whitecaps | 2 | Gauld, Teibert |
| Sporting | 1 | Russell | ||
| 28ª Semana | ||||
| 20-oct-2021 | Cincinnati | Cincinnati | 3 | Acosta, Vazquez, Blackett |
| Fire | 4 | Beric (2), Medran, Stojanovic | ||
| 20-oct-2021 | Washington | DC United | 2 | Robertha, Abila |
| Revolution | 3 | Buksa, Gil, Bou | ||
| 20-oct-2021 | Atlanta | Atlanta United | 1 | Moreno |
| New York City | 1 | Torarinsson | ||
| 20-oct-2021 | Fort Lauderdale | Inter | 3 | Higuain, Makoun, Zavaleta (A) |
| Toronto | 0 | |||
| 20-oct-2021 | Orlando | Orlando City | 1 | Mueller |
| Impact | 1 | Camacho | ||
| 20-oct-2021 | Frisco | Dallas | 2 | Hollingshead, Jara |
| Los Angeles | 3 | Arango (3, 1P) | ||
| 20-oct-2021 | Saint Paul | Minnesota United | 3 | Hunou, Lod, Fragapane |
| Union | 2 | Gazdag (2) | ||
| 20-oct-2021 | Houston | Dynamo | 0 | |
| Galaxy | 3 | Kljestan (P), Valentin (A), Cabral | ||
| 20-oct-2021 | Nashville | Nashville | 1 | Mukhtar |
| Crew | 1 | Zelarayan | ||
| 20-oct-2021 | Commerce City | Rapids | 1 | Badji |
| Sounders | 1 | Roldan | ||
| 20-oct-2021 | Portland | Timbers | 2 | Chara, Asprilla |
| Whitecaps | 3 | Caicedo, White, Dajome (P) | ||
| 20-oct-2021 | San Jose | Earthquakes | 4 | Lopez, Kilanovic, Wondolowski, Fierro |
| Austin | 0 | |||
| 23-oct-2021 | Seattle | Sounders | 1 | Benezet |
| Sporting | 2 | Walter, Russell | ||
| 23-oct-2021 | Columbus | Crew | 1 | Berry |
| Red Bulls | 2 | Casseres, Nealis | ||
| 23-oct-2021 | Bronx | New York City | 6 | Thiago, Castellanos (2), Moralez, Callens, Medina |
| DC United | 0 | |||
| 23-oct-2021 | Chester | Union | 1 | Przybylko (P) |
| Nashville | 0 | |||
| 23-oct-2021 | Toronto | Toronto | 1 | Altidore |
| Montreal | 1 | Sunusi | ||
| 23-oct-2021 | Saint Paul | Minnesota United | 1 | Alonso |
| Los Angeles | 1 | Arango | ||
| 23-oct-2021 | Bridgeview | Fire | 1 | Beric |
| Real Salt Lake | 0 | |||
| 23-oct-2021 | Fort Lauderdale | Inter | 5 | F. Higuain, G. Higuain, Vassilev, Morgan |
| Cincinnati | 1 | Vazquez | ||
| 23-oct-2021 | Commerce City | Rapids | 2 | Badji, Rubio |
| Timbers | 0 | |||
| 23-oct-2021 | San Jose | Earthquakes | 1 | Kikanovic |
| Whitecaps | 1 | Bruno Gaspar | ||
| 23-oct-2021 | Carson | Galaxy | 2 | Hernandez (P), Lletget |
| Dallas | 2 | Ferreira, Jara | ||
| 24-oct-2021 | Austin | Austin | 2 | Maric (A), Driussi |
| Dynamo | 1 | Cascante (A) | ||
| 24-oct-2021 | Orlando | Orlando City | 2 | Nani, Dike (P) |
| Revolution | 2 | Buksa (2) | ||
| 29ª Semana | ||||
| 26-oct-2021 | Los Angeles | Los Angeles | 3 | Rodriguez, Blessing, Arango |
| Seattle | 0 | |||
| 27-oct-2021 | Foxborough | Revolution | 1 | Buchanan |
| Rapids | 0 | |||
| 27-oct-2021 | Cincinnati | Cincinnati | 3 | Romney (A), Brenner, Vazquez |
| Nashville | 6 | Zimmerman, Leal (2), Sapong (2), Loba | ||
| 27-oct-2021 | Bronx | New York City | 1 | Castellanos (P) |
| Fire | 0 | |||
| 27-oct-2021 | Washington | DC United | 1 | Paredes |
| Red Bulls | 0 | |||
| 27-oct-2021 | Atlanta | Atlanta United | 2 | Luiz Araujo, Martinez |
| Inter | 1 | Higuain (P) | ||
| 27-oct-2021 | Columbus | Crew | 3 | Berry, Etienne, Zelarayan |
| Orlando City | 2 | Dike (P), Jansson | ||
| 27-oct-2021 | Toronto | Toronto | 2 | Altidore, Elliott (A) |
| Union | 2 | Bedoya, Sergio Santos | ||
| 27-oct-2021 | Frisco | Dallas | 1 | Hedges |
| Real Salt Lake | 2 | Kreilach, Rusnak | ||
| 27-oct-2021 | Kansas City | Sporting | 2 | Russell (2) |
| Galaxy | 0 | |||
| 27-oct-2021 | Portland | Timbers | 2 | Chara, Asprilla |
| Earthquakes | 0 | |||
| 27-oct-2021 | Vancouver | Whitecaps | 2 | Boxall (A), White |
| Minnesota United | 1 | Adi | ||
| 30-oct-2021 | Fort Lauderdale | Inter | 1 | Figal |
| New York City | 3 | Castellanos (2), Talles Magno | ||
| 30-oct-2021 | Sandy | Real Salt Lake | 3 | Rusnak (2), Chang |
| Earthquakes | 4 | Fierro, Wondolowski, Cowell, Yueill | ||
| 30-oct-2021 | Carson | Red Bulls | 1 | Fabio |
| Montreal | 0 | |||
| 30-oct-2021 | Atlanta | Atlanta United | 1 | Luiz Araujo |
| Toronto | 1 | Perruzza | ||
| 30-oct-2021 | Washington | DC United | 1 | Arriola |
| Crew | 3 | Zelarayan (2, 1P), Pedro Santos | ||
| 30-oct-2021 | Frisco | Dallas | 2 | Ferreira, Jara |
| Austin | 1 | Fagundez | ||
| 31-oct-2021 | Saint Paul | Minnesota United | 2 | Frangapane, Reynoso (P) |
| Sporting | 1 | Shelton | ||
| 31-oct-2021 | Houston | Dynamo | 0 | |
| Rapids | 1 | Badji | ||
| 31-oct-2021 | Orlando | Orlando City | 1 | Dike |
| Nashville | 1 | Mukhtar | ||
| 31-oct-2021 | Chester | Union | 2 | Gazdag, Aaronson |
| Cincinnati | 0 | |||
| 1-nov-2021 | Seattle | Sounders | 1 | Ruidiaz (P) |
| Galaxy | 1 | Hernandez | ||
| 30ª Semana | ||||
| 2-nov-2021 | Los Angeles | Los Angeles | 1 | Fall |
| Whitecaps | 1 | Dajome | ||
| 3-nov-2021 | Montreal | Impact | 2 | Camacho, Miller |
| Dynamo | 0 | |||
| 3-nov-2021 | Harrison | Red Bulls | 0 | |
| Atlanta United | 0 | |||
| 3-nov-2021 | Austin | Austin | 3 | Driussi, Cascante, Stroud |
| Sporting | 1 | Russell | ||
| 3-nov-2021 | Sandy | Real Salt Lake | 1 | Rusnak (P) |
| Timbers | 3 | Blanco (2), Herrera (A) | ||
| 7-nov-2021 | Cincinnati | Cincinnati | 1 | Bailey |
| Atlanta United | 2 | Robinson, Martinez | ||
| 7-nov-2021 | Columbus | Crew | 2 | Zelarayan, Berry |
| Fire | 0 | |||
| 7-nov-2021 | Nashville | Nashville | 1 | Mukhtar |
| Red Bulls | 1 | Fabio | ||
| 7-nov-2021 | Foxborough | Revolution | 0 | |
| Inter | 1 | Matuidi | ||
| 7-nov-2021 | Bronx | New York City | 1 | Castellanos |
| Union | 1 | Przybylko | ||
| 7-nov-2021 | Toronto | Toronto | 1 | Laryea |
| DC United | 3 | Birnbaum, Kamara (2, 1P) | ||
| 7-nov-2021 | Montreal | Impact | 0 | |
| Orlando City | 2 | Mendez, Dike | ||
| 7-nov-2021 | Commerce City | Rapids | 5 | Lewis (2), Warner, Bassett, Badji |
| Los Angeles | 2 | Arango, Rodriguez | ||
| 7-nov-2021 | Carson | Galaxy | 3 | Lletget, Hernandez (2) |
| Minnesota United | 3 | Hunou, Lod, Araujo (A) | ||
| 7-nov-2021 | Portland | Timbers | 3 | Paredes, Niezgoda, Blanco |
| Austin | 0 | |||
| 7-nov-2021 | San Jose | Earthquakes | 1 | Wondolowski |
| Dallas | 1 | Obrian | ||
| 7-nov-2021 | Kansas City | Sporting | 0 | |
| Real Salt Lake | 1 | Kreilach | ||
| 7-nov-2021 | Vancouver | Whitecaps | 1 | Gauld |
| Sounders | 1 | Montero (P) | ||
| Playoffs | ||||
| 20-nov-2021 | Chester | Union | 1 | Glesnes |
| Red Bulls | 0 | |||
| 20-nov-2021 | Kansas City | Sporting | 3 | Shelton, Isimat-Mirin, Zusi |
| Whitecaps | 1 | Dajome (P) | ||
| 21-nov-2021 | Bronx | New York City | 2 | Castellanos, Callens |
| Atlanta United | 0 | |||
| 21-nov-2021 | Portland | Timbers | 3 | Mabiala, Blanco (2) |
| Minnesota United | 1 | Fragapane | ||
| 23-nov-2021 | Nashville | Nashville | 3 | Mukhtar (2), Cadiz |
| Orlando City | 1 | Dike | ||
| 24-nov-2021 | Seattle | Sounders | 0(5) | |
| Real Salt Lake | 0(6) | |||
Semifinales
Conferencia |
||||
| 25-nov-2021 | Commerce City | Rapids | 0 | |
| Timbers | 1 | Mabiala | ||
| 28-nov-2021 | Kansas City | Sporting | 1 | Russell (P) |
| Real Salt Lake | 2 | Julio, Wood | ||
| 28-nov-2021 | Chester | Union | 1(2) | Gazdag |
| Nashville | 1(0) | Mukhtar | ||
| 30-nov-2021 | Foxborough | Revolution | 2(3) | Buksa, Buchanan |
| New York City | 2(5) | Rodriguez, Castellanos | ||
Finales Conferencia |
||||
| 4-dic-2021 | Portland | Timbers | 2 | Mora, Moreno |
| Real Salt Lake | 0 | |||
| 5-dic-2021 | Chester | Union | 1 | Callens (A) |
| New York City | 2 | Moralez, Talles Magno | ||
| FINAL MLS | ||||
| 11-dic-2021 | Portland | Timbers | 1(2) | Mora |
| New York City | 1(4) | Castellanos | ||